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Study identifier: NCT06374459 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis

Condition: Hormone Receptor Positive HER-2 Negative Metastatic Breast Cancer  ·  Sponsor: Washington University School of Medicine

PhasePhase 1/Phase 2
Planned participants152
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase Ib/II study evaluating the safety and efficacy of zunsemetinib (ATI-450) with capecitabine in patients with hormone receptor-positive and HER2-negative (HR+/HER2-) metastatic breast cancer (MBC).

This description comes directly from the study's public registry record.

Talk to the study team

Cynthia X Ma, M.D., Ph.D.  ·  314-362-8903  ·  cynthiaxma@wustl.edu

Always discuss trial participation with your own doctor first.

Locations (3)

The University of Kansas Cancer CenterWestwood, Kansas, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesNot Yet Recruiting
Washington University School of MedicineSt Louis, Missouri, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06374459