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Study identifier: NCT06373016 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Condition: Bipolar Disorder · Bipolar Disorder Type 1  ·  Sponsor: Stony Brook University

PhaseNA
Planned participants100
Who can joinAll sexes, 18 Years to 45 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior.

This description comes directly from the study's public registry record.

Talk to the study team

Stephen Burke, BS  ·  914-325-0868  ·  stephen.j.burke@stonybrook.edu

Sadia Jumana, BS  ·  339-241-2515  ·  sadiaanjum.jumana@stonybrook.edu

Always discuss trial participation with your own doctor first.

Locations (3)

McLean HospitalBelmont, Massachusetts, United StatesRecruiting
Martinos Center for Biomedical Research, Building 149, 13th StreetCharlestown, Massachusetts, United StatesRecruiting
Laufer Center for Physical and Quantitative Biology , Stony Brook UniversityStony Brook, New York, United StatesActive Not Recruiting

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Source record: clinicaltrials.gov/study/NCT06373016