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Study identifier: NCT06372717 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Investigate APL-4098 Alone and in Combination in Adults With AML or MDS

Condition: Acute Myeloid Leukemia Refractory · Myelodysplastic Syndrome Acute Myeloid Leukemia · Myelodysplastic Syndrome With Excess Blasts  ·  Sponsor: Apollo Therapeutics Ltd

PhasePhase 1
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, Phase 1 study to determine the safety, tolerability, and efficacy of APL-4098 alone, and in combination with azacitidine, and in combination with azacitidine plus venetoclax for the treatment of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS)/AML and MDS-excess blasts (EB).

This description comes directly from the study's public registry record.

Talk to the study team

Apollo Therapeutics  ·  781-479-2267  ·  AP30@apollotx.com

Always discuss trial participation with your own doctor first.

Locations (9)

Monash HealthClayton, Victoria, AustraliaRecruiting
St. Vincent's Hospital MelbourneFitzroy, Victoria, AustraliaRecruiting
The Alfred HospitalMelbourne, Victoria, AustraliaRecruiting
Hollywood Private HospitalNedlands, Western Australia, AustraliaActive Not Recruiting
Royal Perth HospitalPerth, Western Australia, AustraliaRecruiting
University Hospital of WalesCardiff, United KingdomRecruiting
Beatson West of Scotland Cancer CentreGlasgow, United KingdomRecruiting
The Royal Marsden HospitalLondon, United KingdomRecruiting
Sarah Cannon Research Institute UKLondon, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT06372717