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Study identifier: NCT06371417 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

Condition: Antiphospholipid Syndrome (APS) · Bullous Pemphigoid (BP) · Behçet's Syndrome (BS)  ·  Sponsor: Chugai Pharmaceutical

PhasePhase 1
Planned participants144
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose administration in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) and immune thrombocytopenia (ITP).

This description comes directly from the study's public registry record.

Talk to the study team

Clinical trials information  ·  only use Email  ·  clinical-trials@chugai-pharm.co.jp

Always discuss trial participation with your own doctor first.

Locations (77)

University of California-IrvineOrange, California, United StatesRecruiting
Johns Hopkins UniversityBaltimore, Maryland, United StatesRecruiting
Northwell Health, LLC PRIMELake Success, New York, United StatesWithdrawn
Hospital for Special SurgeryNew York, New York, United StatesWithdrawn
Universtity of North Carolina at Chapel HillChapel Hill, North Carolina, United StatesRecruiting
Ohio State UniversityColumbus, Ohio, United StatesWithdrawn
Oregon Health & Science UniversityPortland, Oregon, United StatesRecruiting
University of Pennsylvania, Perelman Center for Advanced MedicinePhiladelphia, Pennsylvania, United StatesRecruiting
Amarillo Center for Clinical ResearchAmarillo, Texas, United StatesWithdrawn
Austin Neuromuscular CenterAustin, Texas, United StatesRecruiting
Nerve and Muscle Center of TexasHouston, Texas, United StatesRecruiting
Royal Prince Alfred HospitalCamperdown, New South Wales, AustraliaRecruiting

+ 65 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06371417