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Study identifier: NCT06371404 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

Condition: Alcohol Use Disorder · Post Traumatic Stress Disorder  ·  Sponsor: Yale University

PhaseN/A
Planned participants150
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersYes

About this study

The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurrent PTSD and AUD with control groups. While there are a large number of studies conducted in preclinical stress and addiction models, these findings have not been translated to people living with these disorders. This study will examine relationships between HDAC6 and clinical variables of interest. Findings could direct treatment development.

This description comes directly from the study's public registry record.

Talk to the study team

Kelly Cosgrove  ·  2037376969  ·  kelly.cosgrove@yale.edu

Marc Grasso, Ba  ·  2037377074  ·  marc.grasso@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Yale UniversityNew Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06371404