● Recruiting

Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia

Condition: AML With Gene Mutations · Sponsor: Lomond Therapeutics Holdings, Inc.

PhasePhase 1

Planned participants150

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

This is a clinical study aiming to assess pharmacokinetics, pharmacodynamics and preliminary efficacy of ZE46-0134 in patients with FLT3 and spliceosome mutated Relapsed or Refractory Acute Myeloid Leukemia

This description comes directly from the study's public registry record.

Talk to the study team

Kate Dokukina, PhD, MD · +38269728309 · kdokukina@eileanther.com

Always discuss trial participation with your own doctor first.

Locations (23)

University of California, Los Angeles	Los Angeles, California, United States	Recruiting
University of California, San Francisco	San Francisco, California, United States	Recruiting
Emory University	Atlanta, Georgia, United States	Recruiting
The University of Chicago	Chicago, Illinois, United States	Recruiting
University of Kansas	Lawrence, Kansas, United States	Recruiting
University of Maryland	College Park, Maryland, United States	Recruiting
Memorial Sloan Kettering Cancer Center	New York, New York, United States	Recruiting
University of North Carolina	Chapel Hill, North Carolina, United States	Recruiting
University of Cincinnati	Cincinnati, Ohio, United States	Recruiting
The Ohio State University	Columbus, Ohio, United States	Recruiting
Oregon Health & Science University	Portland, Oregon, United States	Recruiting
The University of Texas Southwestern Medical Center	Dallas, Texas, United States	Recruiting

+ 11 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06366789