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Study identifier: NCT06366347 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ALPINE: Maintenance Letrozole/Abemaciclib

Condition: Endometrial Cancer · Recurrent Endometrial Cancer · TP53  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 2
Planned participants32
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this research study is to see if the study drugs abemaciclib and letrozole are effective and safe for participants with estrogen-receptor positive (ER+), mismatch repair proficient, tumor protein p53 (TP53) wild-type endometrial cancer. The names of the study drugs involved in this study are: * Abemaciclib (a type of cyclin-dependent kinase (CDK) inhibitor) * Letrozole (a type of aromatase inhibitor)

This description comes directly from the study's public registry record.

Talk to the study team

Panagiotis Konstantinopoulos, MD, PhD  ·  617-632-2334  ·  Panagiotis_Konstantinopoulos@DFCI.HARVARD.EDU

Always discuss trial participation with your own doctor first.

Locations (6)

Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer Institute at FoxboroughFoxborough, Massachusetts, United StatesWithdrawn
Dana-Farber Cancer Institute at MilfordMilford, Massachusetts, United StatesWithdrawn
Dana-Farber Cancer Institute at South Shore HospitalWeymouth, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06366347