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Study identifier: NCT06363734 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

Condition: Non-small Cell Lung Cancer · EGFR Activating Mutation · Cell Cycle Deregulation  ·  Sponsor: Tianjin Medical University Cancer Institute and Hospital

PhasePhase 2
Planned participants32
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study is a prospective, single-arm, phase II trial. It is aimed to evaluate the efficacy and safety of the combination of osimertinib and dalpiciclib in patients with EGFR-mutant, CDK4/6 pathway aberrant, advanced NSCLC following acquired resistance to third-generation EGFR TKI.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (1)

Department of Thoracic Medical Oncology, Tianjin Medical University Cancer HospitalTianjin, Tianjin Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06363734