Condition: Pulmonary Embolism · Sponsor: Peking Union Medical College Hospital
1. Integrate pharmacokinetic-pharmacodynamic (PK-PD) modeling and pharmacogenomics techniques to develop a population PK-PD model, aiming to explore monitoring and dose guidance schemes for Direct Oral Anticoagulants (DOACs). 2. Investigate the factors influencing PK-PD of DOACs in the pulmonary embolism population, clarifying the correlation between genotype characteristics and clinical outcomes. 3. Explore the correlation between drug concentrations, coagulation indices, and clinical outcomes of DOACs, defining the indications for DOACs testing and the overall monitoring process.
This description comes directly from the study's public registry record.
juhong Shi, M.D · +8613701178492 · shijh@pumch.cn
yiyao Li, M.D · 18510797366 · yiyo927@163.com
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| Peking Union Medical College Hospital | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06362343