Condition: Central Nervous System Infections · Sponsor: RenJi Hospital
Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis. The mortality rate of ventriculitis is generally reported to be higher than 30%, with the highest reaching over 75%. Even among survivors, over 60% suffer from a variety of neurological sequelae, including cognitive impairment, gait disturbances, paralysis, behavioral disorders, and epilepsy. Currently, treatments for ventriculitis recommended by guidelines primarily focus on the selection and administration of antibiotics, while the effects of surgical interventions have not been fully elucidated. In recent years, several studies have explored the use of ventricular irrigation in ventriculitis, indicating that ventricular irrigation techniques may accelerate the control of ventricular infection, mitigate damage to the central nervous system caused by infections, improve the prognosis of ventriculitis, and reduce complications such as hydrocephalus. However, current studies are still relatively scarce, and mostly case reports and retrospective studies. High-quality evidence is still lacking for the application of ventricular irrigation in ventriculitis. This multicenter randomized controlled trial aims to explore the safety and effectiveness of ventricular irrigation compared to conventional treatment for ventriculitis, analyze the effectiveness of ventricular irrigation across different pathogen …
This description comes directly from the study's public registry record.
Jiyao Jiang, Dr · 021-68383729 · jiyaojiang@126.com
Junfeng Feng, Dr · 13611860825 · fengjfmail@163.com
Always discuss trial participation with your own doctor first.
| The First Affiliated Hospital of University of Science and Technology of China | Hefei, Anhui, China | Not Yet Recruiting |
| The Second People's Hospital of Anhui Province | Hefei, Anhui, China | Not Yet Recruiting |
| The First Affiliated Hospital of Wannan Medical College | Wuhu, Anhui, China | Not Yet Recruiting |
| Xuanwu Hospital Capital Medical University | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| The First Affiliated Hospital of Fujian Medical University | Fuzhou, Fujian, China | Not Yet Recruiting |
| Nanfang Hospital, Southern Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Zhujiang Hospital of Southern Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Shenzhen Second People's Hospital | Shenzhen, Guangdong, China | Not Yet Recruiting |
| Zhongshan Hospital of Traditional Chinese Medicine | Zhongshan, Guangdong, China | Not Yet Recruiting |
| The First Affiliated Hospital of Harbin Medical University | Harbin, Heilongjiang, China | Not Yet Recruiting |
| Henan Provincial People's Hospital | Zhengzhou, Henan, China | Not Yet Recruiting |
| Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology | Wuhan, Hubei, China | Recruiting |
+ 23 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06358209