Condition: Knee Osteoarthritis · Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
As an activator of inhibiting nuclear factor kB receptor, denosumab affects osteoclast differentiation and development by inhibiting OPG/RANKL-RANK bone regulatory axis pathway. Therefore, denosumab is widely used in the treatment of bone diseases such as osteoporosis. Osteoporosis is closely related to knee osteoarthritis. RANKL-RANK pathway also plays a key role in the pathogenesis of knee osteoarthritis. Therefore, the investigators propose the hypothesis that denosumab can effectively treat knee osteoarthritis.
This description comes directly from the study's public registry record.
Tian Hongtao, Doctorate · 18627171618 · tianhongtao@vip.163.com
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| Wuhan Union Hospital | Wuhan, Hubei, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06357741