Condition: Acute Leukemia · Sponsor: Nantes University Hospital
CXCR4 inhibition may represent a new therapeutic strategy in acute leukemia (AL) patients, not only by increasing chemosensitivity but also by preventing relapse of the disease by disruption of the interaction of residual leukemic cells with the bone marrow niche. Radiolabeled CXCR4 ligands have been developed for PET imaging (68Ga-PentixaFor; INN: Gallium (68Ga) boclatixafortide) and radioligand therapy (RLT) (\[177Lu\]Lu-PentixaTher/\[90Y\]Y-PentixaTher). \[177Lu\]Lu and \[90Y\]Y-PentixaTher have been tested in three multiple myeloma patients in named-patient use with a remarkable efficacy in 2 patients (Herrmann, 2016). Moreover, feasibility of CXCR4 PET imaging in AML was reported, providing a framework for future theranostic approaches targeting the CXCR4/CXCL12-defined leukemia-initiating cell niche (Herhaus, 2016). Here a Phase I/II study to determine maximal tolerated dose (MTD) of a RLT using \[177Lu\]Lu-PentixaTher in relapsed/refractory AL was designed. This will be a standard phase I/II 3+3 dose escalation study. Five dose levels will be tested, so 6 to 21 patients have to be included in the study.
This description comes directly from the study's public registry record.
Patrice CHEVALLIER · 02 40 08 39 94 · patrice.chevallier@chu-nantes.fr
Always discuss trial participation with your own doctor first.
| CHU de Bordeaux | Bordeaux, Gironde, France | Recruiting |
| CHU de Nantes | Nantes, Loire-Atlantique, France | Recruiting |
| CHU d'Angers | Angers, Maine et Loire, France | Recruiting |
| CHU de Clermont-Ferrand | Clermont-Ferrand, Puy de Dôme, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06356922