Condition: Locally Advanced Esophageal Squamous Cell Carcinoma · Neoadjuvant Therapy · Sponsor: Sun Jing
The purpose of this study is to investigate the efficacy and safety of neoadjuvant treatment of locally advanced esophageal squamous carcinoma with a PD-1/CTLA-4 bispecific antibody (Cadonilimab) in combination with platinum-containing chemotherapy (Paclitaxel Polymeric Micelles for Injection combined with Cisplatin). Includes pathologic complete remission rates (pCR rates) after 2-4 cycles of Cadonilimab combination chemotherapy. The objective remission rate (ORR), major pathologic remission rate (MPR), R0 resection rate and 2-year overall survival (OS) and progression-free survival (OS) rates, and safety of neoadjuvant treatment of locally advanced esophageal squamous carcinoma with Cadonilimab combined with chemotherapy.
This description comes directly from the study's public registry record.
Jing Sun · 13914704178 · sunj@njmu.edu.com
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| the First Affiliated Hospital of Nanjing Medical University | Nanjing, Jiangsu, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06356688