Condition: Liver Transplantation · Immunosuppression · Sponsor: University Hospital, Limoges
World Health Organization considers non-adherence has a strong negative impact on the health of patients with chronic diseases. In transplantation, adherence to immunosuppressive drug regimens associates with late rejection and graft loss making it a critical determinant of patient outcome. The prevalence of non-adherence in transplant patients, including liver transplant patients, can be as high as 40%. Among others, life-long intake and complexity of immunosuppressive regimen make patients prone to non-adherence. For instance, non-adherence is more prevalent among patients with higher numbers of immunosuppressive drugs. One of the most commonly cited causes of non-adherence is forgetfulness and disruptions in routine, with the evening dose of twice daily regimens being the most likely to be affected6. Besides non-adherence, the constraints generated in everyday life by immunosuppression (including timely and regular drug intake) and the complexity of the immunosuppressive regimens represent a burden for the patients and are probably associated with a health-related quality of life deterioration. Therefore, long-term adherence and quality of life after liver transplantation might be improved by using a well-tolerated and easy-to-handle immunosuppressive regimen. The immunosuppressive regimen after liver transplantation is in most cases based on different combinations of tacrolimus, mycophenolate mofetil and corticosteroids. While corticosteroids are administered once daily,…
This description comes directly from the study's public registry record.
Caroline MONCHAUD, Pharm D · 555056140 · caroline.monchaud@inserm.fr
Hélène ROUSSEL · helene.roussel@chu-limoges.fr
Always discuss trial participation with your own doctor first.
| CHU de Besançon - Hôpital Jean Minjoz | Besançon, France | Recruiting |
| Beaujon hospital - APHP | Clichy, France | Recruiting |
| CHU de Dijon Bourgogne | Dijon, France | Recruiting |
| CHu de Grenoble | Grenoble, France | Not Yet Recruiting |
| Lille university hospital | Lille, France | Recruiting |
| Limoges university hospital | Limoges, France | Recruiting |
| Lyon university hospital | Lyon, France | Recruiting |
| APHP | Marseille, France | Recruiting |
| Montpellier university hospital | Montpellier, France | Recruiting |
| Nice university hospital | Nice, France | Recruiting |
| Pitie Salpetriere hospital - APHP | Paris, France | Recruiting |
| Bordeaux university hospital | Pessac, France | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06354179