Condition: Epilepsy · Angelman Syndrome · Dup15q Syndrome · Sponsor: IRCCS Eugenio Medea
Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks. Indeed, this has helped to identify functionally altered areas in patients with temporal epilepsy by simply using the resting EEG signal. Furthermore, it has been seen that the propagation of neuronal avalanches (VNs) correlates with the morphological organization of the cerebral cortex. Therefore, NAs represent a measure with direct utility for studying functional reorganization pre and post drug/surgical treatment. In addition, the aperiodic portion of the signal may represent a noninvasive measure of the excitation/inhibition relationship, which is known of being altered both in epilepsy and in some rare neurodevelopmental syndromes (example: Angelman and Dup15q)
This description comes directly from the study's public registry record.
Gian Marco Duma, PhD · +39 0438414248 · gianmarco.duma@lanostrafamiglia.it
Darling Boachie · +39 0438 41242 · segreteriascientifica.medea.veneto@lanostrafamiglia.it
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| IRCCS E.Medea | Conegliano, Treviso, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06353620