Condition: Ischemic Stroke, Acute · Sponsor: The George Institute
Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients. Although two trials indicate harm from very intensive target-based treatment (SBP \<130 mmHg), the others neutral effects in the SBP range 140-160 mmHg. The ENCHANTED3/MT domain of the ACT-GLOBAL platform trial aims to test different approaches to the treatment of elevated SBP in post-EVT AIS patients to find an optimal BP management strategy. ENCHANTED3/MT will randomize (1:1:1) up to 2,000 patients with SBP ≥150 mmHg post-EVT to conservative (no or minimal SBP reduction by 5-10mmHg or a target of 175-180mmHg if very-high baseline SBP \[≥180mmHg\]), moderate (SBP reduction by 10-20mmHg or a target of 160 ± 5, whichever is higher; no control if low-high baseline SBP \[150-160mmHg\]), or intensive (SBP reduction by 30-50mmHg or a target of 140±5 mmHg, whichever is higher) BP management.
This description comes directly from the study's public registry record.
Xiaoying Chen, PhD · +61 2 8052 4549 · xchen@georgeinstitute.org.au
Craig Anderson, PhD · +61 2 8052 4521 · canderson@georgeinstitute.org.au
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| The George Institute for Global Health | Sydney, New South Wales, Australia | Recruiting |
| University of Calgary | Calgary, Alberta, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06352619