Condition: Thrombocythemia, Essential · Primary Myelofibrosis · Myelofibrosis · Sponsor: Merck Sharp & Dohme LLC
The primary purpose of the study is to transition participants into an extension study to collect long-term safety and efficacy data. The study will include participants who are safely tolerating bomedemstat, receiving clinical benefit from its use in estimation of the investigator, and have shown the following criteria: * Participants from the IMG-7289-202/MK-3543-005 (NCT05223920) study must have received at least 6 months of treatment with bomedemstat; * Essential thrombocythemia (ET) and polycythemia vera (PV) participants from studies other than IMG-7289-202/MK-3543-005 must have achieved confirmed hematologic remission. No hypothesis testing will be conducted in this study.
This description comes directly from the study's public registry record.
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| University of Michigan ( Site 6000) | Ann Arbor, Michigan, United States | Recruiting |
| DUHS Duke Blood Cancer Center ( Site 6005) | Durham, North Carolina, United States | Recruiting |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 6007) | Columbus, Ohio, United States | Recruiting |
| UPMC Hillman Cancer Center ( Site 6004) | Pittsburgh, Pennsylvania, United States | Recruiting |
| Royal Prince Alfred Hospital ( Site 1003) | Camperdown, New South Wales, Australia | Recruiting |
| Royal North Shore Hospital ( Site 1001) | St Leonards, New South Wales, Australia | Recruiting |
| Sunshine Coast Hematology and Oncology Clinic ( Site 1006) | Buderim, Queensland, Australia | Recruiting |
| Gold Coast University Hospital-Cancer and Blood Disorders Clinical Trial Team ( Site 1002) | Southport, Queensland, Australia | Recruiting |
| Royal Adelaide Hospital-Haematology Clinical Trials Unit ( Site 1000) | Adelaide, South Australia, Australia | Recruiting |
| Monash Health ( Site 1004) | Clayton, Victoria, Australia | Recruiting |
| Queen Mary Hospital ( Site 1601) | Hksar, Hong Kong | Active Not Recruiting |
| Azienda Ospedaliera Universitaria Careggi ( Site 2700) | Florence, Tuscany, Italy | Recruiting |
+ 9 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06351631