Condition: Gender Dysphoria · Sponsor: Assistance Publique - Hôpitaux de Paris
Gender dysphoria (GD) is a significant suffering lasting more than 6 months in a subject, with regard to the discrepancy felt between his or her gender identity and his or her birth sex. From the onset of puberty, most of these self-identified transgender adolescents will persist in their transgender identity and will undergo hormonal and surgical reassignment when the time comes. International best practice guidelines recommend early treatment from the start of pubertal development to block pubertal progression, with the possibility of hormonal transition by administering sex hormones of the desired sex usually around the age of 16. However, in order to reduce the psychosocial consequences of GD, more and more referral teams are carrying out this transition from the age of 14, although no study has been published to show its benefit compared with a transition at the age of 16. In the absence of treatment, co-morbidity among adolescents suffering from gender dysphoria is very high, with anxiety-depressive states, suicidal risk and dropping out of school in the forefront. Our hypothesis is that hormonal transition started at an age closer to physiological puberty can significantly reduce this comorbidity and improve quality of life for these adolescents. This is the first therapeutic trial to be conducted in France in the transgender adolescent population, in an area where international recommendations based on the principles of Evidence Based Medicine are essentially derived …
This description comes directly from the study's public registry record.
David COHEN, MD,PhD · 01 42 16 23 51 · david.cohen@aphp.fr
Anne BISSERY · (0)142162432 · anne.bissery@aphp.fr
Always discuss trial participation with your own doctor first.
| Service de psychiatrie de l'enfant et de l'adolescent, GH Pitié-Salpêtrière | Paris, Paris, France | Recruiting |
| Service d'Endocrinologie et Diabétologie Pédiatrique, CHU Robert Debré | Paris, Paris, France | Recruiting |
| Service de Psychiatrie de l'enfant et de l'adolescent, CHU Robert Debré | Paris, Paris, France | Recruiting |
| Service Endocrinologie et Diabète de l'enfant, CHU Le Kremlin Bicêtre | Le Kremlin-Bicêtre, Île-de-France Region, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06351501