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Study identifier: NCT06349772 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

Condition: Post Operative Pain  ·  Sponsor: Texas Tech University Health Sciences Center

PhaseEARLY_Phase 1
Planned participants130
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersYes

About this study

The purpose of this study is to evaluate the use of an injectable combination of bupivacaine and meloxicam (Zynrelef) vs injectable liposomal bupivacaine (Exparel), two extended local anesthesia strategies currently approved by FDA and on the market for post-surgical pain control. The investigators plan on randomizing study participants to either Exparel or Zynrelef at the closure site of robotic sleeve gastrectomy and assessing their pain control postoperatively both in the hospital and at home. The investigators will measure the outcome of two drugs, Zynrelief, and Exparel on postoperative pain score -using the NRS pin score up to 72 hours after surgery. The total opioid use will be recorded in forms that will be used to measure pain score and total opioid use and will be collected to the Excel sheet. The cost of the drug will be calculated for internal use for Hospital purpose only.

This description comes directly from the study's public registry record.

Talk to the study team

Tommy Wright, DO  ·  8176888021  ·  tommy.wright@ttuhsc.edu

Vinay Goyal, MD  ·  vinay.goyal@ttuhsc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Texas Tech University Health Sciences CenterLubbock, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06349772