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Study identifier: NCT06349083 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD

Condition: Alcohol Use Disorder  ·  Sponsor: NYU Langone Health

PhasePhase 2
Planned participants200
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This is a double-blind, randomized, placebo-controlled Phase 2 mechanistic clinical trial designed to evaluate the therapeutic neural mechanisms of psilocybin in patients with alcohol use disorder (AUD), and to determine whether further studies are warranted to study the relationship of any such effects to clinical improvement in AUD symptoms. The primary aims are to evaluate the effects of psilocybin on AUD; measures will include 1) fMRI neural activation and functional connectivity, using a well-validated task to characterize neural and subjective response to negative affective and alcohol visual stimuli; 2) alcohol use data (self-report and blood biomarkers); and 3) self-report measures related the NE, IS, and EF domains.

This description comes directly from the study's public registry record.

Talk to the study team

Michael Bogenschutz, MD  ·  646-501-4026  ·  Michael.bogenschutz@nyulangone.org

Gillian Monty  ·  646-754-3440  ·  gillian.monty@nyulangone.org

Always discuss trial participation with your own doctor first.

Locations (1)

NYU Langone HealthNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06349083