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Study identifier: NCT06349044 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies.

Condition: Her-2 Negative Adenocarcinoma of the Gastro-oesophageal Junction/Gastric Adenocarcinoma · Hepatocellular Carcinoma · Biliary Tract Carcinoma  ·  Sponsor: Zhejiang Cancer Hospital

PhaseNA
Planned participants120
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

Based on the interaction between radiation therapy and immunotherapy and the potential potentiation of Probio-M9 for the treatment of ICIs, this study is planned to design an integrated treatment protocol for the first-line treatment of advanced gastrointestinal tumors through the use of macrofractionated radiotherapy as a means of immune activation, combined with the synergistic effect of Probio-M9 microbial agents and PD-1 inhibitors.

This description comes directly from the study's public registry record.

Talk to the study team

zhu ji  ·  13501978674  ·  zhuji@zjcc.org.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Zhengjiang Cancer HospitalHangzhou, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06349044