Condition: Neuroendocrine Tumors · Sponsor: Australasian Gastro-Intestinal Trials Group
Neuroendocrine tumours (NETs) are slow growing cancers, which commonly present as metastatic incurable disease. Some neuroendocrine tumours, termed functional NETs, overproduce hormones which result in a variety of symptoms. However, approximately 75% of NETs are considered non-functional meaning that they do not result in hormone overproduction. The main treatment for both functional and non-functional NETs is somatostatin analogues (SSA, a type of inhibitory hormone). These drugs slow tumour growth and reduce hormone production. Over time, the majority of patients will experience tumour growth despite treatment with SSA therapy. When this occurs, the addition of Peptide Receptor Radionuclide Therapy (PRRT, a type of targeted radiotherapy) in combination with ongoing SSA therapy is given. However, it is not known if continuing SSA therapy after commencement of PRRT is beneficial or not. The aim of this study is to estimate the outcomes of patients with grade 1 and 2 well differentiated mid, hind-gut or pancreatic neuroendocrine tumours who have progressed on SSA therapy and receive subsequent PRRT with or without concurrent SSA.
This description comes directly from the study's public registry record.
Julia Kuszewski · +61 02 7208 2725 · agitg_stopnet_mailbox@gicancer.org.au
Always discuss trial participation with your own doctor first.
| Royal North Shore Hospital | Sydney, New South Wales, Australia | Recruiting |
| Wollongong Hospital | Wollongong, New South Wales, Australia | Recruiting |
| Royal Brisbane and Womens Hospital | Brisbane, Queensland, Australia | Recruiting |
| The Queen Elizabeth Hospital | Adelaide, South Australia, Australia | Recruiting |
| Peter MacCallum Cancer Centre | Melbourne, Victoria, Australia | Recruiting |
| Fiona Stanley Hospital | Perth, Western Australia, Australia | Recruiting |
| BC Cancer Agency, Vancouver Cancer Centre | Vancouver, British Columbia, Canada | Recruiting |
| London Health Sciences Centre Research Institute (LHSCRI) | London, Ontario, Canada | Recruiting |
| Ottawa Hospital Research Institute | Ottawa, Ontario, Canada | Recruiting |
| Odette Cancer Centre Sunnybrook Health Sciences Centre | Toronto, Ontario, Canada | Recruiting |
| Allan Blair Cancer Centre | Regina, Saskatchewan, Canada | Recruiting |
| Saskatoon Cancer Centre | Saskatoon, Saskatchewan, Canada | Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06345079