← Eichor
Study identifier: NCT06343402 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

Condition: Non-small Cell Lung Cancer · Metastatic Non-Small Cell Lung Cancer · NSCLC  ·  Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

PhasePhase 1
Planned participants350
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab and BBO-10203 in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.

This description comes directly from the study's public registry record.

Talk to the study team

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)  ·  650-405-8440  ·  onkoras-101ct.gov@bridgebiooncology.com

Always discuss trial participation with your own doctor first.

Locations (35)

O'Neal Comprehensive Cancer Center at UABBirmingham, Alabama, United StatesRecruiting
University of California - San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
University of California San FranciscoSan Francisco, California, United StatesRecruiting
UCLA Health - Santa Monica Cancer CareSanta Monica, California, United StatesRecruiting
University of Colorado Cancer CenterAurora, Colorado, United StatesRecruiting
Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Norwalk HospitalNorwalk, Connecticut, United StatesRecruiting
OSF Saint Francis Medical CenterPeoria, Illinois, United StatesRecruiting
University of Kansas Medical CenterKansas City, Kansas, United StatesRecruiting
Henry Ford Cancer - DetroitDetroit, Michigan, United StatesRecruiting
Roswell Park Cancer InstituteBuffalo, New York, United StatesRecruiting
Perlmutter Cancer Center - NYU Langone HealthNew York, New York, United StatesRecruiting

+ 23 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06343402