Condition: Ocular Myasthenia Gravis · Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Myasthenia is an autoimmune disease causing dysfunction of the neuromuscular junction, resulting in fluctuating and variable muscle weakness. In the initial phase of the disease, 70% of patients present with ocular onset myasthenia (OMG), i.e. weakness limited to the oculomotor muscles. Generalization to skeletal, bulbar and axial muscles occurs in 20-40% of cases, with a higher frequency in the first and second years, respectively 46% and 60% of generalizations. This reflects the maturation of the autoimmune response in the early years of the disease, and represents a therapeutic window of opportunity to modify the course of the disease. Generalization is a critical event, putting the patient at risk of admission to an intensive care unit and necessitating the use of long-term immunosuppressants. There is currently no validated strategy for preventing generalization. On the one hand, a preventive role for corticosteroid therapy in ocular-onset myasthenia has been observed in some studies, but not confirmed by others. These contradictory results may be explained by the bias of retrospective observational studies and the use of different corticosteroid administration regimens. On the other hand, recent data on the use of low-dose Rituximab in the early phase of the disease shows greater efficacy than later use, enabling prolonged remission of the disease with a very good tolerability profile. We propose to compare in a randomized controlled trial the usual practice with a…
This description comes directly from the study's public registry record.
Antoine Gueguen · +33148036852 · agueguen@for.paris
Always discuss trial participation with your own doctor first.
| Centre Hospitalier Universitaire De Bordeaux | Bordeaux, France | Recruiting |
| Hôpital Raymond Pointcarre | Garches, France | Not Yet Recruiting |
| Centre Hospitalier Universitaire De Lille | Lille, France | Recruiting |
| Hospices Civils De Lyon | Lyon, France | Recruiting |
| Centre Hospitalier Universitaire De Nice | Nice, France | Recruiting |
| CHNO | Paris, France | Active Not Recruiting |
| Hôpital de la Pitié-Salpêtrière | Paris, France | Not Yet Recruiting |
| Centre Hospitalier Sainte Anne | Paris, France | Active Not Recruiting |
| Fondation Adolphe de Rothschild | Paris, France | Recruiting |
| Les Hopitaux Universitaires De Strasbourg | Strasbourg, France | Recruiting |
| Centre Hospitalier Universitaire De Toulouse | Toulouse, France | Active Not Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06342544