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Study identifier: NCT06337292 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

Condition: Fracture of Tibia · Wound Heal · Infected Wound  ·  Sponsor: Major Extremity Trauma Research Consortium

PhasePhase 3
Planned participants352
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft fracture with incision \>3cm. Eligible participants will be randomized to receive either incisional negative pressure wound therapy (NPWT) or a non-suction standard-of-care wound dressing for their definitive wound management. The primary outcome will be a composite outcome to evaluate clinical status 3 months after randomization.

This description comes directly from the study's public registry record.

Talk to the study team

Leah Gitajn, MD  ·  603-650-5133  ·  ida.leah.gitajn@hitchcock.org

Always discuss trial participation with your own doctor first.

Locations (6)

University of Maryland R Adams Cowley Shock Trauma CenterBaltimore, Maryland, United StatesRecruiting
University of Maryland Shock Trauma/Capitol RegionsBaltimore, Maryland, United StatesRecruiting
Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire, United StatesRecruiting
Vanderbilt UniversityNashville, Tennessee, United StatesRecruiting
UTHealth/McGovern Medical SchoolHouston, Texas, United StatesRecruiting
Inova Fairfax MEdical CampusFalls Church, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06337292