Condition: Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes · Sponsor: IRCCS SYNLAB SDN
The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.
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| Irccs Synlab Sdn | Naples, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06337227