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Study identifier: NCT06336824 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia

Condition: Staphylococcus Aureus Bacteremia  ·  Sponsor: Clinical Research Centre, Malaysia

PhasePhase 3
Planned participants290
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus aureus Bacteraemia (EVOS) study is a multicentre, randomized, open-label, parallel group, phase 3, non-inferiority trial of early intravenous to oral antibiotic switch in comparison with standard intravenous antibiotic regime among patients with uncomplicated Staphylococcus aureus bacteraemia (SAB). The study is based on the hypothesis that an early switch from IV to oral antimicrobial therapy is non-inferior and safe compared to conventional minimum 14-day course of IV therapy in patients with low-risk uncomplicated SAB.

This description comes directly from the study's public registry record.

Talk to the study team

Steven Lim, MBBS, MRCP  ·  +60133620081  ·  stevenlimcl@gmail.com

Josephine P Durai, MBBS  ·  +6052085146  ·  joeyukijo.28@gmai.com

Always discuss trial participation with your own doctor first.

Locations (12)

Hospital Sultanah AminahJohor Bahru, Johor, MalaysiaRecruiting
Hospital Sultanah BahiyahAlor Star, Kedah, MalaysiaRecruiting
Hospital Sultan Abdul HalimSungai Petani, Kedah, MalaysiaRecruiting
Hospital Tuanku Ja'afarSeremban, Negeri Sembilan, MalaysiaRecruiting
Hospital Raja Permaisuri BainunIpoh, Perak, MalaysiaRecruiting
Hospital Pulau PinangGeorge Town, Pulau Pinang, MalaysiaRecruiting
Hospital Seberang JayaSeberang Jaya, Pulau Pinang, MalaysiaRecruiting
Hospital AmpangAmpang, Selangor, MalaysiaRecruiting
Hospital Sultan Idris Shah SerdangKajang, Selangor, MalaysiaRecruiting
Hospital Tengku Ampuan RahimahKlang, Selangor, MalaysiaRecruiting
Hospital SelayangSelayang Baru Utara, Selangor, MalaysiaRecruiting
Hospital MelakaMalacca, MalaysiaRecruiting

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Source record: clinicaltrials.gov/study/NCT06336824