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Study identifier: NCT06336798 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Bioenergetic Effect of Pioglitazone in CLD-PH

Condition: Pulmonary Hypertension · Pulmonary Hypertension Due to Lung Diseases  ·  Sponsor: Emory University

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn about the safety and efficacy of Pioglitazone in people with Pulmonary Hypertension (PH) due to Chronic Lung Disease (CLD). The main question it aims to answer is: • Whether pioglitazone affects mitochondrial oxygen utilization in patients with PH due to CLD. Participants will be asked to take pioglitazone or placebo once daily for 28 days followed by a washout period of 2 weeks followed by 28 days of the other study drug (participants randomized to placebo followed by pioglitazone or pioglitazone followed by placebo).

This description comes directly from the study's public registry record.

Talk to the study team

Aaron Trammell, MD, MSc  ·  404-712-8204  ·  awtramm@emory.edu

Jane Gillespie, RN  ·  404-712-8204  ·  jegille@emory.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Emory Healthcare SystemAtlanta, Georgia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06336798