Condition: Acute Myocardial Infarction · Cardiovascular Diseases · Inflammatory Response · Sponsor: Region Örebro County
The goal of this randomized, double-blind, placebo-controlled clinical trial is to investigate the immunological effects of influenza vaccination outside of the influenza season on arterial inflammation in patients with a recent acute myocardial infarction (AMI). The primary objective is to compare the effects of influenza vaccination to those of a placebo in reducing post-myocardial infarction coronary inflammation as measured by coronary computed tomography angiography (CCTA). The main questions it aims to answer are: Does influenza vaccination reduce arterial inflammation as measured by CCTA at week 8 after percutaneous coronary intervention (PCI) in comparison to baseline? Does influenza vaccination modulate systemic inflammation as measured by blood biomarkers and in-vitro challenge tests at week 8 after PCI in comparison to baseline? Researchers will compare the effects of influenza vaccination with those of a placebo.
This description comes directly from the study's public registry record.
Sara Cajander, MD · +46196021042 · sara.cajander@oru.se
Always discuss trial participation with your own doctor first.
| Aarhus University Hospital, Department of Cardiology | Aarhus, Denmark | Recruiting |
| Örebro University Hospital | Örebro, Sweden | Recruiting |
| Cambridge University Hospitals NHS Foundation Trust | Cambridge, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06336317