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Study identifier: NCT06336031 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Impact of Blood Phobia on Fainting Susceptibility

Condition: Syncope, Vasovagal · Blood, Injection, Injury Type Phobia  ·  Sponsor: Simon Fraser University

PhaseNA
Planned participants20
Who can joinAll sexes, 18 Years to 50 Years
Healthy volunteersYes

About this study

The primary purpose of this study is to characterize cardiovascular autonomic function to emotional stimuli (blood-injection-injury phobia \[needle phobia\]) during an orthostatic (upright) challenge in individuals with and without known needle phobia. It is well established that emotional stress can produce hypotensive (low blood pressure) reactions. Interestingly, these hypotensive reactions to venipuncture (even with minimal blood drawn), insulin injections, finger sticks for blood sugar monitoring, dental care, and vaccinations can affect up to a quarter of adults and appear to be uniquely associated with blood-injection-injury phobia rather than other phobias. These hypotensive reactions can ultimately lead to a vasovagal syncope (fainting) response, and lead to increased avoidance of medical and dental procedures as a result of this phobia. Ultimately, this has severe implications on public health and places additional strain on the Canadian healthcare system. Currently, there is limited understanding surrounding the initiation of this response. Additionally, a comprehensive profile of cardiovascular autonomic function during exposure to provoking stimuli during orthostatic stress has not been captured in the literature. We will test individuals with and without blood-injection-injury phobia using our standard approach while exposing them to emotional stimuli.

This description comes directly from the study's public registry record.

Talk to the study team

Victoria E Claydon, PhD  ·  7787828513  ·  victoria_claydon@sfu.ca

Vera E Lucci, PhD  ·  7787828560  ·  vlucci@sfu.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Simon Fraser UniversityBurnaby, British Columbia, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06336031