Condition: Colorectal Neoplasia · Screening Colonoscopy · Colorectal Cancer · Sponsor: Vestre Viken Hospital Trust
Colorectal cancer (CRC), the third most diagnosed cancer and second most common cause of cancer death. CRCs develop from precursors like adenomas (about 70% of CRCs) or serrated lesions (SSLs) (about 25-30% of CRCs). Colonoscopy is the cornerstone in CRC screening, in screening programmes often as a work-up examination after a positive primary screening test such as faecal immunochemical test (FIT). Norway and Sweden have recently launched a nationwide faecal haemoglobin CRC screening programmes. Recently, both a Dutch and an Austrian study showed that SSL detection rate (SSLDR) is inversely correlated to CRC at follow-up. Consequently, improved SSLDR can reduce the risk of post-colonoscopy CRC. SSLs are typically located in the right colon. They are flat, with indistinctive boarders, and consequently easily missed or incompletely resected. A Norwegian study showed incomplete resection of 40% of proximal SSLs. The prevalence of SSLs is higher in women than in men, with women being on a threefold risk of developing CRC from SSLs. It seems like post-colonoscopy CRC more often is caused by SSLs than by adenomas. Total underwater colonoscopy (TUC) is a technique replacing conventional CO2 insufflation by water infusion to distend the lumen and visualise the mucosa during withdrawal of the colonoscope and simultaneously removal of water. There are several reasons to advocate TUC: 1. SSLs will be more visible as they "float" on the submucosa and contract into the lumen, while full…
This description comes directly from the study's public registry record.
Anna Lisa Schult, MD, PhD · +47 67 80 94 00 · anschu@vestreviken.no
Thomas de Lange, MD, associate prof · thomas.de.lange@gu.se
Always discuss trial participation with your own doctor first.
| Vestre Viken Health Trust, Bærum Hospital | Drammen, Norway | Recruiting |
| Østfold Hospital Health Trust | Grålum, Norway | Recruiting |
| Akershus University Hospital Health Trust | Lørenskog, Norway | Recruiting |
| Ullevål University Hospital Health Trust | Oslo, Norway | Recruiting |
| Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden, Department of Medicine, Geriatrics and Emergency Care Mölndal | Gothenburg, Sweden | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06333392