Condition: Coronary Artery Disease · Myocardial Infarction · Acute Coronary Syndrome · Sponsor: Queen Mary University of London
There is a lack of understanding of how Coronary Artery Disease (CAD) - meaning the blocking or furring up of the arteries of the heart - starts and progresses in women. In both men and women, CAD is the most common cause of heart attacks, which occur when the blood supply in the heart is interrupted (these are also known medically as 'acute coronary syndromes'). Before the menopause women appear to be protected from CAD; however, after the menopause that protection is lost. Also, those women who do suffer a heart attack have twice the risk of further heart attacks compared to men despite having the same treatment that works well in men. Biological differences between men and women are probably playing an important role in the way CAD develops. However, due to a lack of research there is currently little understanding of how the female body works in this area. Inflammation is the body's natural response to injury or infection. Importantly it is also involved in the development of CAD. Hormones such as oestrogen and testosterone are also likely to be contributory factors. The investigators think the differences between the way these hormones and inflammation play a part in CAD in both men and women are important, but the role they play is not yet fully understood. In this study the investigators wish to measure the 'markers' of inflammation in the blood of patients attending Barts Heart Centre with chest pain. The investigators will also conduct questionnaires with these pa…
This description comes directly from the study's public registry record.
Krishnaraj Rathod, MBBS PhD · 020 7882 5720 · k.s.rathod@qmul.ac.uk
Amrita Ahluwalia, BSc PhD · 020 7882 5720 · a.ahluwalia@qmul.ac.uk
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Source record: clinicaltrials.gov/study/NCT06327984