Condition: Alcohol Use Disorder · Sponsor: William Stoops
This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people with Alcohol Use Disorder. This study will also provide basic science information about the orexinergic mechanisms underlying the pharmacodynamic effects of alcohol in humans. As such, the outcomes will contribute to our understanding of the clinical neurobiology of Alcohol Use Disorder. Overall, the proposed work seeks to expand the scope of current clinical neuroscience research on alcohol addiction by focusing on orexin, which has strong preclinical evidence supporting its critical role in addiction but remains unstudied in humans.
This description comes directly from the study's public registry record.
William W Stoops, PhD · 8592575388 · william.stoops@uky.edu
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| Psychopharmacology of Addiction Laboratory | Lexington, Kentucky, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06326684