Condition: Hematologic Malignancy · ALL, Childhood · AML, Childhood · Sponsor: St. Jude Children's Research Hospital
The study participant has one of the following blood cancers: acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (B-ALL, T-ALL) or Lymphoma. Your cancer has been difficult to treat (refractory) or has come back after treatment (relapse). Primary Objective To determine the safety and maximum tolerated dose of intravenous infusions of escalating doses of CD70-CAR T cells in patients (≤21 years) with recurrent/refractory CD70+ hematological malignancies after lymphodepleting chemotherapy. Secondary Objectives To evaluate the antileukemic activity of CD70-CAR T cells. We will determine the anti- leukemic activity of the CD70-CAR T cells in the bone marrow and in the treatment of extramedullary disease.
This description comes directly from the study's public registry record.
Swati Naik, MBBS · 866-278-5833 · referralinfo@stjude.org
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| St. Jude Children's Research Hospital | Memphis, Tennessee, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06326463