Condition: Recurrent Meningioma · Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Novel treatments are urgently needed for meningiomas progressing after local therapies (surgery, radiotherapy). So far, no effective systemic therapies are known in this situation. The LUMEN-1 trial will investigate in a prospective randomized trial the efficacy of the precision medicine "theranostic" concept of combining diagnostic patient selection using PET-based molecular imaging and target-specific therapeutic intervention using a systemically administered radioligand. The rationale for the LUMEN-1 trial is based on the following: (a) high somatostatin receptor (SSTR) expression in meningiomas, (b) wide-spread availability of clinically established SSTR-PET imaging, (c) proven efficacy of SSTR-targeting radioligand therapy using \[177Lu\]Lu-DOTATATE in another tumor type (neuroendocrine tumors), and (d) promising experiences with \[177Lu\]Lu-DOTATATE therapy in compassionate use applications and retrospective case series and interim results from one ongoing uncontrolled prospective trial in meningiomas. LUMEN-1 is the first randomized clinical trial to investigate \[177Lu\]Lu-DOTATATE therapy in refractory meningioma and may open new avenues for treatment and research in this area.
This description comes directly from the study's public registry record.
EORTC · +32 2 774 16 11 · eortc@eortc.org
Always discuss trial participation with your own doctor first.
| A.O Landeskrankenhaus - Innsbruck Universitaetsklinik | Innsbruck, Austria | Recruiting |
| Universitaetskliniken der Uni Wien - Universitaetsklinikum Wien - AKH unikliniken | Vienna, Austria | Recruiting |
| Centre Leon Berard | Lyon, France | Recruiting |
| CHU de Lyon - CHU Lyon - Hopital neurologique Pierre Wertheimer | Lyon, France | Recruiting |
| Assistance Publique - Hopitaux de Marseille APHM - Hopital de La Timone (APHM) | Marseille, France | Recruiting |
| Centre Eugene Marquis | Rennes, France | Recruiting |
| CHU de Toulouse - Institut Claudius Regaud - IUCT oncopole | Toulouse, France | Recruiting |
| CHRU de Nancy - Hopitaux De Brabois | Vandœuvre-lès-Nancy, France | Recruiting |
| Gustave Roussy | Villejuif, France | Recruiting |
| Universitaetsklinikum - Essen | Essen, Germany | Recruiting |
| University Frankfurt - Goethe Univ. - University Hospital Frankfurt- Klinik für Neurologie Funktionsbereich Neuroonkologie | Frankfurt, Germany | Recruiting |
| Universitaetsklinikum Heidelberg - UniversitaetsKlinikum Heidelberg - Head Hospital | Heidelberg, Germany | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06326190