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Study identifier: NCT06325852 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Directional Bilateral Thalamic Patterned Stimulation (Chronos)

Condition: Essential Tremor  ·  Sponsor: Alfonso Fasano

PhaseNA
Planned participants15
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

Population Size and Eligible Patients: The investigators aim to recruit 5 to 10 patients with tremors who have previously undergone Ventral Intermedius Deep Brain Stimulation (VIM-DBS) treatment but have experienced early or late loss of benefits. Additionally, the investigators will enroll ten patients with essential tremor who require VIM-DBS surgery. These individuals will undergo bilateral implantation of Boston Scientific Genus Implantable Pulse Generator (IPG) devices, connected to Boston Scientific Cartesia™ 8-contact Directional Leads. Study Design: This study comprises two distinct phases. Phase 1 is a cross-sectional investigation designed to identify the optimal algorithm for patterned stimulation in the VIM region . Phase 2 is a prospective clinical trial focusing on the assessment of safety and efficacy of bilateral VIM-DBS in patients with essential tremor. Objectives: The primary objective in Phase 2 is to evaluate the safety and effectiveness of bilateral VIM-DBS in individuals with essential tremor. In Phase 1, the investigators seek to explore the impact of the Chronos programming software on tremor patients who have experienced early or late loss of benefits.

This description comes directly from the study's public registry record.

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Locations (1)

Movement Disorders Centre - Toronto Western HospitalToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06325852