Condition: Fabry Disease · Chronic Kidney Diseases · Sponsor: Caroline Michaela Kistorp
The overall objective of this study is to investigate Fabry-associated renal organ involvement by using a novel magnetic resonance imaging (MRI) approach, focusing on changes in renal oxygen levels by blood oxygenation-level dependent (BOLD) imaging. Furthermore, to correlate renal oxygenation to the phenotypic presentation of patients with Fabry-associated nephropathy regarding circulating and imaging-derived biomarkers of kidney inflammation, fibrosis and injury as compared with healthy age- and sex-matched controls. The study will achieve this by: 1\) Using a non-invasive, contrast-free MRI protocol focusing on parameters of oxygenation, inflammation, fibrosis, and injury in the kidney. 2\) Using an extensive, in-depth biomarker blood panel to investigate the pathological pathways associated with Fabry disease and Fabry-associated nephropathy.
This description comes directly from the study's public registry record.
Caroline M Kistorp, Professor · 35 45 96 42 · caroline.michaela.kistorp@regionh.dk
Niels H Brandt-Jacobsen, MD, PhD · 41 81 30 07 · niels.hoeeg.brandt-jacobsen.01@regionh.dk
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| Rigshospitalet | Copenhagen, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06325488