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Study identifier: NCT06321588 Synced from ClinicalTrials.gov · July 28, 2026
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Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment

Condition: Cognitive Impairment · Dementia  ·  Sponsor: Azienda Usl di Bologna

PhaseN/A
Planned participants300
Who can joinAll sexes, 40 Years to 90 Years
Healthy volunteersNo

About this study

The goal of this observational study is to investigate the frequency and the possible pathogenic role of neuronal synaptic antibodies (NSAb) in patients with cognitive impairment (CI). The main questions it aims to answer are: 1. the frequency and associated features of NSAb in patients with CI and the usefulness of a clinical score in improving autoimmune dementia (AID) diagnosis; 2. the clinical significance of NSAb in patients with CI not fulfilling the autoimmune encephalitis (AE) criteria and serum NSAb (NSAb-pos-CI); 3. the impact of blood-brain-barrier (BBB) dysfunction on their pathogenicity.

This description comes directly from the study's public registry record.

Talk to the study team

Maria Pia Giannoccaro, Dr.  ·  +390514966112  ·  mariapia.giannoccaro@ausl.bologna.it

Always discuss trial participation with your own doctor first.

Locations (3)

IRCCS Istituto delle Scienze Neurologiche di BolognaBologna, Bologna, ItalyRecruiting
Istituto Auxologico Italiano IRCCSMilan, Milano, ItalyRecruiting
Fondazione IRCCS Istituto Neurologico Carlo BestaMilan, Milano, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06321588