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Study identifier: NCT06321081 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC

Condition: RAS Mutation · Metastatic Colorectal Cancer · MSS  ·  Sponsor: Beijing Hospital

PhasePhase 2
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a non-profit phase II, open, clinical study of the combination of irinotecan plus cetuximab and envafolimab as a rechallenge regimen, in pre-treated RAS/BRAF wild type metastatic colorectal cancer patients (according to liquid biopsy at baseline). Patients have been treated in front lines with irinotecan and cetuximab and had a clinical benefit (complete or partial response) from both of them, no matter whether they had treated by any PD-1 inhibitor before.

This description comes directly from the study's public registry record.

Talk to the study team

Yingying Huang  ·  86 010 85136715  ·  yinghh@hotmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Beijing HospitalBeijing, Beijing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06321081