Condition: Acute Ischemic Stroke AIS · Stroke Acute · Stroke, Acute, Stroke Ischemic · Sponsor: University of Calgary
This domain has a prospective, randomized, controlled, open-label, parallel group with blinded endpoint assessment (PROBE) design. Up to 4,000 patients with presumed acute ischemic stroke (AIS) will be followed for 90 days (or until death, if prior to 90 days). The end of the trial is defined as the date that all participants have completed their Day 90 assessment. This domain aim is to efficiently, reliably, and simultaneously, determine the comparative effectiveness of intravenous thrombolysis (IVT) using standard-dose intravenous tenecteplase (0.25 mg/kg body weight), vs. low-dose intravenous tenecteplase (0.18 mg/kg body weight) in all patients who present to hospital with acute ischemic stroke and are considered for intravenous thrombolysis. In addition, this domain also seeks to study standard-dose intravenous tenecteplase (0.25 mg/kg body weight), vs. low-dose intravenous tenecteplase (0.18 mg/kg body weight) vs. no TNK upfront with rescue IA TNK if necessary (in those eligible for emergency EVT) and no TNK upfront in those who have taken DOACs during the preceding 48 hours. This domain therefore seeks to generate more robust randomized evidence to guide clinicians in their decisions over the balance of risks and treatment with intravenous thrombolysis with tenecteplase wherever such evidence is currently insufficient. This domain will currently evaluate four research questions in relation to the use of IVT with tenecteplase: 1. In patients with recent (48 hours) in…
This description comes directly from the study's public registry record.
Bijoy K Menon, MD · 4039448107 · bkmmenon@ucalgary.ca
Craig Anderson, MD · 4039448107 · canderson@georgeinstitute.org.au
Always discuss trial participation with your own doctor first.
| The George Institute for Global Health | Sydney, Barangaroo, Australia | Not Yet Recruiting |
| Royal Prince Alfred Hospital | Sydney, New South Wales, Australia | Recruiting |
| Monash University (Box Hill) | Melbourne, Victoria, Australia | Recruiting |
| University of Calgary | Calgary, Alberta, Canada | Recruiting |
| Medicine Hat Regional Hospital | Medicine Hat, Alberta, Canada | Not Yet Recruiting |
| Red Deer Regional Hospital | Red Deer, Alberta, Canada | Not Yet Recruiting |
| University of Alberta | Edmonton, A, Canada | Recruiting |
| Kelowna Regional Hospital | Kelowna, British Columbia, Canada | Not Yet Recruiting |
| Royal Columbian Hospital | New Westminster, British Columbia, Canada | Not Yet Recruiting |
| University of British Columbia | Vancouver, British Columbia, Canada | Recruiting |
| Brandon Regional Hospital | Brandon, Manitoba, Canada | Not Yet Recruiting |
| University of Manitoba - Winnipeg Health Science Centre | Winnipeg, Manitoba, Canada | Recruiting |
+ 12 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06320431