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Study identifier: NCT06319248 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

Condition: Sepsis · Low Blood Pressure  ·  Sponsor: Mayo Clinic

PhasePhase 2
Planned participants308
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being done to determine if early administration of Midodrine can improve outcomes by maintaining a higher mean blood pressure off of intravenous medications. Researchers want to see if Midodrine can help people with sepsis need fewer vasopressors, which could mean shorter hospital stays, less time with uncomfortable tubes, and a smoother recovery overall.

This description comes directly from the study's public registry record.

Talk to the study team

Amy Schuchard  ·  507-255-0148  ·  Schuchard.Amy@mayo.edu

Aysun Tekin, MD, MS  ·  347-421-9114  ·  Tekin.Aysun@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (5)

Mayo Clinic ArizonaScottsdale, Arizona, United StatesRecruiting
Mayo Clinic FloridaJacksonville, Florida, United StatesRecruiting
Mayo Clinic Health System - MankatoMankato, Minnesota, United StatesRecruiting
Mayo Clinic MinnesotaRochester, Minnesota, United StatesRecruiting
Mayo Clinic Health System - Eau ClaireEau Claire, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06319248