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Study identifier: NCT06315010 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis

Condition: NSCLC · Brain Metastases · ROS1 Gene Rearrangement  ·  Sponsor: MedSIR

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

REPOSE is a phase II clinical trial exploring the safety and efficacy of repotrectinib in patients with non-small cell lung cancer (NSCLC) characterized by the presence of brain metastasis (BM) and whose tumors have mutated ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) gene.

This description comes directly from the study's public registry record.

Talk to the study team

MEDSIR  ·  +34 93 2214135  ·  contact.trials@medsir.org

Always discuss trial participation with your own doctor first.

Locations (16)

Medizinische Universität GrazGraz, AustriaRecruiting
Medical University of ViennaVienna, AustriaRecruiting
Ludwig-Maximilians-University MunichMünchen, GermanyRecruiting
Hospital de VinalopóElche, Alicante, SpainRecruiting
Hospital Universitari Sant Joan de ReusReus, Tarragona, SpainRecruiting
Hospital General Universitario Dr. BalmisAlicante, SpainRecruiting
Hospital de CrucesBarakaldo, SpainRecruiting
UOMI Cancer CenterBarcelona, SpainRecruiting
Hospital Universitari Vall d'HebronBarcelona, SpainRecruiting
Institut Català d' Oncologia Girona (ICO)Girona, SpainRecruiting
Hospital Universitario de LeónLeón, SpainRecruiting
Hospital Lucus AgustiLugo, SpainRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06315010