Condition: Breast Neoplasms · Sponsor: Merck Sharp & Dohme LLC
The purpose of this study is to compare sacituzumab tirumotecan as a single agent, and in combination with pembrolizumab, versus Treatment of Physician's Choice (TPC) in participants with hormone receptor positive/human epidermal growth factor receptor-2 negative (HR+/HER2-) unresectable locally advanced, or metastatic, breast cancer. The primary hypotheses are that sacituzumab tirumotecan as a single agent and sacituzumab tirumotecan plus pembrolizumab are superior to TPC with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent central review (BICR) in all participants.
This description comes directly from the study's public registry record.
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Always discuss trial participation with your own doctor first.
| Ironwood Cancer & Research Centers ( Site 0066) | Chandler, Arizona, United States | Recruiting |
| Banner MD Anderson Cancer Center-Oncology ( Site 0004) | Gilbert, Arizona, United States | Recruiting |
| Providence Medical Foundation-Oncology ( Site 0020) | Fullerton, California, United States | Recruiting |
| Moores Cancer Center ( Site 0059) | La Jolla, California, United States | Active Not Recruiting |
| Cancer and Blood Specialty Clinic ( Site 0001) | Los Alamitos, California, United States | Recruiting |
| University of Colorado Anschutz Medical Campus ( Site 0061) | Aurora, Colorado, United States | Recruiting |
| UCHealth Cherry Creek Medical Center ( Site 0094) | Denver, Colorado, United States | Recruiting |
| University of Colorado Health - Highlands Ranch Hospital ( Site 0095) | Highlands Ranch, Colorado, United States | Completed |
| Yale Cancer Center ( Site 0060) | New Haven, Connecticut, United States | Recruiting |
| Stamford Hospital ( Site 0049) | Stamford, Connecticut, United States | Recruiting |
| AdventHealth Altamonte Springs ( Site 0021) | Altamonte Springs, Florida, United States | Recruiting |
| University of Florida College of Medicine ( Site 0063) | Gainesville, Florida, United States | Active Not Recruiting |
+ 247 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06312176