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Study identifier: NCT06311838 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness

Condition: Opioid Use Disorder · Dual Diagnosis · Housing Problems  ·  Sponsor: Ohio State University

PhaseNA
Planned participants300
Who can joinAll sexes, 14 Years to 24 Years
Healthy volunteersNo

About this study

Homelessness severely affects health and well-being and is particularly negative for youth. Between 70-95% of youth experiencing homelessness (YEH) report problem substance use and 66-89% have a mental health disorder. Youth appear to be at greater risk for living on the streets or being homeless than adults and are more vulnerable to long term consequences of homelessness. Multiple social determinants of health (SDOH) are uniquely associated with homelessness, driving substance use and adverse mental health consequences. However, limited research has identified pragmatic interventions that have a long-term ameliorating impact on the complex, multi-symptomatic issues among these youth. This study overcomes prior gaps in research through testing a multi-component comprehensive prevention intervention targeting SDOH that may affect biopsychosocial health indicators and longer-term health outcomes. In partnership with a drop-in center for YEH, youth between the ages of 14 to 24 years, will be engaged and randomly assigned to conditions using a dismantling design so that essential intervention components can be efficiently identified. In particular, youth (N = 300) will be randomly assigned to a) Motivational Interviewing/Community Reinforcement Approach + Services as Usual (MI/CRA + SAU, n = 80), b) Strengths-Based Outreach and Advocacy + Services As Usual (SBOA + SAU, n = 80), c) MI/CRA + SBOA + SAU (n = 80) or d) SAU (n=60) through the drop-in center. In order to assess the lo…

This description comes directly from the study's public registry record.

Talk to the study team

Jodi Ford, PhD  ·  614-292-6862  ·  ford.553@osu.edu

Natasha Slesnick, PhD  ·  (614) 247-8469  ·  slesnick.5@osu.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Star HouseColumbus, Ohio, United StatesRecruiting
Ohio State UniversityColumbus, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06311838