Condition: Ulcerative Colitis · Ulcerative Colitis Chronic Moderate · Sponsor: University of California, San Diego
The goal of this observational study is to learn about the mechanism of action of ozanimod in patients with ulcerative colitis (UC). The main questions it aims to answer are: 1. Prospectively assess the effects of ozanimod on the cellular composition of intestinal lamina propria and blood by deep immunophenotyping (CyTOF) of immune cell subsets prior and after the drug's administration. 2. Determine whether changes in cell subsets observed via mass cytometry correlate with with clinical or histologic parameters of disease activity. Colonic biopsies and peripheral blood samples will be collected from patients with UC before and after the onset of ozanimod. Researchers will compare intestinal and peripheral leukocytes before and after the drug's administration.
This description comes directly from the study's public registry record.
Jesus Rivera-Nieves, MD · 8585345495 · jriveran@ucsd.edu
Alyssa Blair · 858-822-4939
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| University of California San Diego | San Diego, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06311123