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Study identifier: NCT06305962 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

Condition: PDL1 Gene Mutation · Non Small Cell Lung Cancer · Small Cell Lung Cancer ( SCLC )  ·  Sponsor: Radiopharm Theranostics, Ltd

PhaseEARLY_Phase 1
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 0/1, First-in-Human (FIH), study to evaluate safety, tolerability, biodistribution, radiation dosimetry and preliminary anti-tumour activities of 177Lu-RAD204 in participants with selected solid tumours, to identify the MTDs/ recommended doses of 177Lu-RAD204 for future exploration. The study will consist of a Pre-screening Period (if applicable for PD-L1 testing), a Screening Period of up to 4 weeks, followed by a Phase 0 (Imaging) Period for imaging and dosimetry to 177Lu-RAD204im and a Phase I (Treatment) Period for 177Lu-RAD204tr dose escalation.

This description comes directly from the study's public registry record.

Talk to the study team

Dimitris Voliotis, MD  ·  +1 646 535 5017  ·  dv@radiopharmtheranostics.com

Always discuss trial participation with your own doctor first.

Locations (5)

Nepean HospitalKingswood, New South Wales, AustraliaRecruiting
Wollongong HospitalWollongong, New South Wales, AustraliaRecruiting
Gold Coast University HospitalSouthport, Queensland, AustraliaRecruiting
Cancer Research SA (CRSA)Adelaide, South Australia, AustraliaRecruiting
GenesisCare MurdochMurdoch, Western Australia, AustraliaRecruiting

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Source record: clinicaltrials.gov/study/NCT06305962