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Study identifier: NCT06305598 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

Condition: Castration-Resistant Prostate Carcinoma · Metastatic Prostate Carcinoma · Stage IVB Prostate Cancer AJCC v8  ·  Sponsor: Roswell Park Cancer Institute

PhasePhase 1
Planned participants14
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase I trial tests the change in androgen receptor sensitivity, side effects and effectiveness of bipolar androgen therapy, using testosterone, in patients with castration resistant prostate cancer that has spread to other places is the body (metastatic). Bipolar androgen therapy is the regulation of testosterone between castration levels (lower than what would be normally present) and supraphysiological levels (amounts greater than normally found in the body). This may suppress cancer cell growth, which reduces prostate-specific antigen (PSA) levels and may delay cancer progression.

This description comes directly from the study's public registry record.

Talk to the study team

ASK RPCI  ·  1-800-845-2300  ·  askroswell@roswellpark.org

Always discuss trial participation with your own doctor first.

Locations (1)

Roswell Park Cancer InstituteBuffalo, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06305598