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Study identifier: NCT06302439 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

PROPEL - A Prospective Observational Patient Registry to Evaluate ENPP1 and ABCC6 Deficiency

Condition: Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Deficiency · ATP-Binding Cassette Subfamily C Member 6 Deficiency  ·  Sponsor: Inozyme Pharma

PhaseN/A
Planned participants1000
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The purpose of this prospective registry is to characterize the natural history of ectonucleotide pyrophosphatase/phosphodiesterase1(ENPP1) Deficiency and the infantile-onset form of adenosine triphosphate (ATP) binding cassette transporter protein subfamily C member 6 (ABCC6) Deficiency longitudinally. The registry will prospectively gather information about the genetic, biochemical, physiological, anatomic, radiographic, and functional manifestations (including patient reported outcomes \[PROs\]) of each disease during routine, standard-of-care visits, with the aim of developing a comprehensive understanding of the burden of illness and progressive nature of the disease.

This description comes directly from the study's public registry record.

Talk to the study team

Jelena Garafalo, Ph.D  ·  (857) 330-4340  ·  jelena.garafalo@inozyme.com

Always discuss trial participation with your own doctor first.

Locations (14)

Ann and Robert H. Lurie Children's HospitalChicago, Illinois, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting
CLINILABS Drug Development CorpEatontown, New Jersey, United StatesRecruiting
The Children's Hospital of Philadelphia (CHOP)Philadelphia, Pennsylvania, United StatesRecruiting
CHU Sainte-Justine Research CentreMontreal, Quebec, CanadaRecruiting
Universitätsklinikum Hamburg-EppendorfHamburg, GermanyRecruiting
IRCCS San Raffaele Hospital - MainMilan, ItalyRecruiting
The University of Tokyo HospitalTokyo, JapanRecruiting
Royal Hospital MuscatMuscat, OmanRecruiting
EU Hub - VCTCBarcelona, SpainRecruiting
Hospital Sant Joan de DeuBarcelona, SpainRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06302439