Condition: Glioblastoma · Sponsor: Iacopo Sardi
Glioblastoma (GBM) and diffuse intrinsic bridge gliomas (DIPG) only the most aggressive forms of cancer, and their prognosis remains bleak. Currently, the standard of treatment is TMZ concomitant with radiotherapy, and, at the end of combined treatment, as adjuvant therapy. In vitro and in vivo experimental studies have suggested that anthracyclines are effective antineoplastics for the treatment of gliomas. In patients with solid tumors treated with anthracyclines, continuous infusion administration compared with bolus administration has been shown to provide a better safety profile especially with regard to cardiotoxicity. Based on this evidence, this study aims to evaluate the safety and antitumor activity of combined treatment with Dox, WBRT (whole body radiotherapy), and TMZ in pediatric and young adult patients affected by GMB
This description comes directly from the study's public registry record.
Iacopo Sardi · 0555662631 · iacopo.sardi@meyer.it
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| Meyer Children's Hospital IRCCS | Florence, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06297512