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Study identifier: NCT06294990 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Klinefelter Syndrome and Testosterone Treatment in Puberty

Condition: Klinefelter Syndrome  ·  Sponsor: Lise Aksglæde

PhasePhase 4
Planned participants32
Who can joinMale, 10 Years to 14 Years
Healthy volunteersNo

About this study

The goal of this randomized clinical trial is to study the effect of testosterone replacement therapy during puberty in boys with Klinefelter syndrome (KS, 47,XXY). The main questions to answer are how treatment with testosterone will affect body fat mass, lipid and glucose metabolism, growth and body proportions, bone mineralization as well as effects on neurocognitive development and emotional and social difficulties. Participants will be randomized to two years treatment with testosterone or placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Lise Aksglaede, MD  ·  +45 35455064  ·  lise.aksglaede@regionh.dk

Always discuss trial participation with your own doctor first.

Locations (1)

Copenhagen University Hospital, RigshospitaletCopenhagen, DenmarkRecruiting

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Source record: clinicaltrials.gov/study/NCT06294990